Which factor would necessitate a reduction in the dosage of disopyramide?

Quinidine

The nurse should consider the drug Quinidine as the cause for these adverse effects. Quinidine toxicity is called cinchonism. Some of its symptoms include ringing in the ears (tinnitus), hearing loss, headache, nausea, vomiting, abdominal pain, dizziness, vertigo, and light-headedness. Lidocaine, flecainide, and procainamide do not cause tinnitus or hearing loss as adverse effects.

Apprehension

Adverse effects of lidocaine are seen particularly in the CV system and CNS. CV effects are related to serum levels; the most severe is cardiac depression coinciding with toxic levels of lidocaine. The most common CV effects are cardiac arrhythmias and hypotension. Other effects include bradycardia and CV collapse, which may lead to cardiac arrest. CNS adverse effects also are related to blood concentrations of lidocaine. The most common CNS effects are dizziness, lightheadedness, fatigue, drowsiness and apprehension. These common, mild effects are seen with low blood levels of lidocaine and resolve rapidly. As blood levels of lidocaine rise, nervousness, confusion, mood changes, hallucinations, euphoria, tinnitus, blurred or double vision, and a sensation of heat, cold, or numbness may occur.

Quinidine

The nurse should consider the drug Quinidine as the cause for these adverse effects. Quinidine toxicity is called cinchonism. Some of its symptoms include ringing in the ears (tinnitus), hearing loss, headache, nausea, vomiting, abdominal pain, dizziness, vertigo, and light-headedness. Lidocaine, flecainide, and procainamide do not cause tinnitus or hearing loss as adverse effects.

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